Biostatistician - University of Alberta (Canadian VIGOUR Centre)

Overview

The Canadian VIGOUR Centre (CVC) has a new opportunity for a dynamic individual interested in becoming part of our leading Academic Research Organization internationally recognized for excellence in the management of large-scale clinical trials (www.vigour.ualberta.ca). We are currently accepting applications for a full-time Biostatistician who, in consultation and collaboration with senior researchers and Faculty of the CVC, will be responsible for designing clinical trials/studies, leading statistical analyses and working on small and large-scale clinical intervention (pharmaceutical and/or device) trials and/or registries in cardiology. Key responsibilities include: Designing clinical trials (including pilots and phases 2 and 3), substudies and registries by providing statistical leadership to the protocol (i.e. statistical analysis plans, fixed versus adaptive design, randomization schemes, power/sample size calculations, interim analyses, data collection tools, etc.) Developing statistical analysis plans to address secondary research questions and/or providing guidance on methodological queries Using statistical and medical understanding to propose and perform additional analyses appropriately and independently Developing and validating statistical programs (i.e., code) to perform analyses and prepare statistical output (tables, listings and figures) Managing small and large databases to create analysis datasets (and associated documentation), and undertaking checks to ensure their validity Preparing written documentation for the clinical trial protocol, reports to government, industry or regulatory agencies, and peer-reviewed academic publications (abstracts, presentations, manuscripts) Keeping abreast of new developments in biostatistics, clinical study design, and cardiovascular disease and care, and sharing these findings with the research team Providing guidance and mentoring junior statisticians/analysts/clinical researchers (e.g. medical students, residents, fellows) Participating in quality assurance of statistical analysis plans, coding and output generated at the CVC Collaborating with local, national and international investigators, statisticians, sponsors, and other stakeholders on specific research projects and creating timelines for statistical project management

Experience and Qualifications

The preferred candidate will have a minimum of a Master's degree in (bio)statistics or related field (PhD will also be considered) with at least 2 years of relevant experience in applied clinical research, including the design of clinical trials/registries and analysis of these data. Equivalent combinations of education and experience will be considered. The individual should possess previous training and experience in clinical trial design and statistical methods commonly used in applied clinical research (e.g., survival analysis, regression, prognostic model development and validation, competing risks/multi-state modeling, inverse probability weighting, and multilevel modeling). This role will require proficiency in software used for data management and statistical analysis (MSAccess, SQL; SAS, R) and the proven ability to develop and/or apply novel statistical methods. Familiarity with REDCap (Research Electronic Data Capture) would be an asset. The ideal candidate will have the ability to work well independently, to manage time multiple projects and other commitments efficiently, and will demonstrate excellent skills in communication (written and verbal) when interacting effectively as a member of the applied clinical research team.